Biphasic Alteration of Butyrylcholinesterase (BChE) During Prostate Cancer Development
نویسندگان
چکیده
منابع مشابه
Role of MDR1 During Prostate Cancer Development
Despite advancements in detection and in treatment of this disease, prostate cancer death rates remain largely unchanged. This is largely due to the heterogeneous biology of prostate cancer, which is characterized by a wide spectrum of clinical behavior ranging from indolent to a rapidly progressing disease. In this manuscript we studied about molecular markers like p53 and MDR1 in prostate can...
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Ghrelin coded by the GHRL gene is related to weight-gain, its deactivation possibly depending on its hydrolyzation by butyrylcholinesterase (BChE) encoded by the BCHE gene, an enzyme already associated with the body mass index (BMI). The aim was to search for relationships between SNPs of the GHRL and BCHE genes with BChE activity, BMI and obesity in 144 obese and 153 nonobese Euro-Brazilian ma...
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Many conditions interfere with butyrylcholinesterase (BChE) activity, e.g., pregnancy or presence of the BCHE gene variant -116A can decrease activity whereas obesity and types I and II diabetes mellitus can increase activity. In this study, we examined BChE activity, -116A and 1615A BCHE gene variants, and anthropometric and biochemical variables associated with diabetes in patients with gesta...
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Human tissues have two distinct cholinesterase activities: acetylcholinesterase and butyrylcholinesterase. Acetylcholinesterase functions in the transmission of nerve impulses, whereas the physiological function of butyryl-cholinesterase remains unknown. An atypical form of butyrylcholinesterase or the absence of its activity leads to prolonged apnea following administration of the muscle relax...
متن کاملButyrylcholinesterase (BCHE) genotyping for post-succinylcholine apnea in an Australian population.
BACKGROUND Measurement of plasma butyrylcholinesterase (BChE) activity and inhibitor-based phenotyping are standard methods for identifying patients who experience post-succinylcholine (SC) apnea attributable to inherited variants of the BChE enzyme. Our aim was to develop PCR-based assays for BCHE mutation detection and implement them for routine diagnostic use at a university teaching hospita...
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ژورنال
عنوان ژورنال: Translational Oncology
سال: 2018
ISSN: 1936-5233
DOI: 10.1016/j.tranon.2018.06.003